Wednesday, May 27, 2020 Current Time : 12:47 In Tehran
Created Date : Wednesday, July 3, 2019  

Omega-3 affects the symptoms of rhinitis


A research project of Kermanshah University of Medical Sciences showed that the omega-3 fatty acid derivatives are effective in improving the symptoms of allergic rhinitis.

Allergic rhinitis (AR) is an inflammatory condition of the nasal mucosa, and inflammation is a defense response of the host to remove harmful agents. While acute inflammation is essential for the health and survival of the host, untreated inflammation may result in chronic inflammation and subsequent tissue damage.

The study showed that inflammation is mainly regulated by specific lipid suppressive mediators derived from essential fatty acids, including omega-6 and omega-3 fatty acids. According to the results of the research project of “comparison of serum levels of resolvin E1 & D1 and expression level of omega-3 receptor gene (GPR120) and PPAR-γ transcription factor in peripheral blood cells of patients with AR with healthy people”, which was carried out by Dr. Farhad Salari in the vice-chancellor for science and technology of Kermanshah University of Medical Sciences, omega-3 fatty acid derivatives (one of the essential fatty acids for the body) are effective in improving the symptoms of allergic rhinitis (inflammation of the nasal mucosa).

The scientific results of the mentioned research revealed that the mean serum levels of RvE1 were significantly higher in patients with AR, compared to healthy individuals (P<0.01). However, no significant difference was found between the two groups regarding RvD1 serum levels. Similarly, there was no significant difference between the groups in terms of expression of GPR120 mRNA. Furthermore, PPAR mRNA significantly decreased in AR patients, compared to healthy individuals.


Regarding the application of the results of this research, it was proposed that Omega-3 fatty acid derivatives be used to eliminate the symptoms of AR in patients.


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